BioLEC Publications

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2024

Grace B. Panetti, Junho Kim, Michele S. Myong, Matthew J. Bird, Gregory D. Scholes, Paul J. Chirik, “Photodriven Ammonia Synthesis from Manganese Nitrides: Photophysics and Mechanistic Investigations”, J. Am. Chem. Soc. 2024, available online.

Alexandra T. Barth,  Austin J. Pyrch, Conor T. McCormick, Evgeny O. Danilov, Felix N. Castellano, “Excited State Bond Homolysis of Vanadium(V) Photocatalysts for Alkoxy Radical Generation”, J. Phys. Chem. A 2024, 128, 7609, available online.

Azka Arshad, Felix N. Castellano,” Homomolecular Triplet–Triplet Annihilation in Metalloporphyrin Photosensitizers”, J. Phys. Chem. A 2024, 128, 7648, available online.

Audrey C. Norris, Catrina Oberg, Leah C. Spangler, Gregory D. Scholes, Gabriela S. Schlau-Cohen, “Discovery of Multiple Light-Harvesting States of the Photosynthetic Protein PE545″, J. Am. Chem. Soc. 2024, available online.

Stephen DiLuzio, Lakshmy Kannadi Valloli, Max Kudisch, Daniel T. Chambers, Garry Rumbles, Obadiah G. Reid, Matthew J. Bird, Hannah J. Sayre, “Reconceptualizing the Ir^III Role in Metallaphotoredox Catalysis: From Strong Photooxidant to Potent Energy Donor”, ACS Catal. 2024, 14, 11378, available online.

Alexander Q. Cusumano, Braden C. Chaffin, Abigail G. Doyle, “Mechanism of Ni-Catalyzed Photochemical Halogen Atom-Mediated C(sp³)–H Arylation”, J. Am. Chem. Soc. 2024, 146, 15331, available online.

Max M. O’Connor, Taylor J. Aubry, Obadiah G. Reid, Garry Rumbles, “Charge Concentration Limits the Hydrogen Evolution Rate in Organic Nanoparticle Photocatalysts”, Adv. Mater. 2024, 36, 2210481, available online.

2023

Amy Y. Chan, Atanu Ghosh, Jonathan T. Yarranton, Jack Twilton, Jian Jin, Daniela M. Arias-Rotondo, Holt A. Sakai, James K. McCusker, David W. C. MacMillan, “Exploiting the Marcus inverted region for first-row transition metal-based photoredox catalysis”, Science 2023, 382, 191, available online.

Angela Lee, Minjung Son, Mawuli Deegbey, Matthew D. Woodhouse, Stephanie M. Hart, Hayden F. Beissel, Paul T. Cesana, Elena Jakubikova, James K. McCusker, Gabriela S. Schlau-Cohen, “Observation of parallel intersystem crossing and charge transfer-state dynamics in [Fe(bpy)3]2+ from ultrafast 2D electronic spectroscopy”, Chem. Sci. 2023, 14, 13140, available online.

Suong T. Nguyen, Lydia R. Fries, James H. Cox, Yuting Ma, Brett P. Fors, Robert R. Knowles, “Chemical Recycling of Thiol Epoxy Thermosets via Light-Driven C–C Bond Cleavage”, J. Am. Chem. Soc. 2023, 145, 11151, available online.

Micheal M. Alowakennu, Atanu Ghosh, James K. McCusker, “Direct Evidence for Excited Ligand Field State-based Oxidative Photoredox Chemistry of a Cobalt(III) Polypyridyl Photosensitizer”, J. Am. Chem. Soc. 2023, 145, 20786, available online.

Yunjung Baek, Adam Reinhold, Lei Tian, Philip D. Jeffrey, Gregory D. Scholes, Robert R. Knowles, “Singly Reduced Iridium Chromophores: Synthesis, Characterization, and Photochemistry”, J. Am. Chem. Soc. 2023, 145, 12499, available online.

Xiankun Li, Claire G. Page, Laura Zanetti-Polzi, Aarat P. Kalra, Daniel G. Oblinsky, Isabella Daidone, Todd K. Hyster, Gregory D. Scholes, “Mechanism and Dynamics of Photodecarboxylation Catalyzed by Lactate Monooxygenase”, J. Am. Chem. Soc. 2023,  145, 13232, available online.

Jesse A. Wisch, Xiao Liu, Patrick J. Sarver, Cesar N. Prieto Kullmer, Agustin Millet, David W. C. MacMillan, Barry P. Rand, “Plasmon Mediated Near-Field Energy Transfer From Solid-State, Electrically Injected Excitons to Solution Phase Chromophores”, Adv. Funct. Mater. 2023, 33, 2214367, available online.

2022

Yuxuan Ye, Jingzhe Cao, Daniel G. Oblinsky, Deeptak Verma, Christopher K. Prier, Gregory D. Scholes, Todd K. Hyster, “Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination”, Nature Chem. 2022, 15, 206, available online.

Nick Y. Shin, Elaine Tsui, Adam Reinhold, Gregory D. Scholes, Matthew J. Bird, Robert R. Knowles, “Radicals as Exceptional Electron-Withdrawing Groups: Nucleophilic Aromatic Substitution of Halophenols Via Homolysis-Enabled Electronic Activation”, J. Am. Chem. Soc. 2022, 144, 21783, available online. 

Emily E. Brown, Iuliia Mandzhieva, Patrick M. TomHom, Thomas Theis, Felix N. Castellano, “Triplet Photosensitized para-Hydrogen Induced Polarization”, ACS Cent. Sci. 2022, 8, 1548, available online.

Sun Dongbang, Abigail Doyle, “Ni/Photoredox-Catalyzed C(sp³)–C(sp³) Coupling between Aziridines and Acetals as Alcohol-Derived Alkyl Radical Precursors”, J. Am. Chem. Soc. 2022, 144, 20067, available online.

Raymundo Moya, Audrey C. Norris, Leah C. Spangler, Gregory D. Scholes, Gabriela S. Schlau-Cohen, “Observation of conformational dynamics in single light-harvesting proteins from cryptophyte algae”, J. Chem. Phys. 2022, 157, 035102, available online.

Paul T. Cesana, Claire G. Page, Dvir Harris, Megan A. Emmanuel, Todd K. Hyster, Gabriela S. Schlau-Cohen, “Photoenzymatic Catalysis in a New Light: Gluconobacter “Ene”-Reductase Conjugates Possessing High-Energy Reactivity with Tunable Low-Energy Excitation”, J. Am. Chem. Soc. 2022, 144, 17516, available online.

Agustin Millet, Paul T. Cesana, Kassandra Sedillo, Matthew J. Bird, Gabriela S. Schlau-Cohen, Abigail G. Doyle, David W. C. MacMillan, Gregory D. Scholes, “Bioinspired Supercharging of Photoredox Catalysis for Applications in Energy and Chemical Manufacturing”, Acc. Chem. Res. 2022, 55, 1423, available online.

 

Tiffany Q. Chen, P. Scott Pedersen, Nathan W. Dow, Remi Fayad, Cory E. Hauke, Michael C. Rosko, Evgeny O. Danilov, David C. Blakemore, Anne-Marie Dechert-Schmitt, Thomas Knauber, Felix N. Castellano, David W. C. MacMillan, “A Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids, J. Am. Chem. Soc. 2022, 144, 8296, available online.

Stephen I. Ting, Wendy L. Williams, Abigail G. Doyle, “Oxidative Addition of Aryl Halides to a Ni(I)-Bipyridine Complex”, J. Am. Chem. Soc. 2022, 144, 5575, available online.

Justin D. Earley, Anna Zieleniewska, Hunter H. Ripberger, Nick Y. Shin, Megan S. Lazorski, Z. J. Mast, Hannah J. Sayre, James K. McCusker, Gregory D. Scholes, Robert R. Knowles, Obadiah G. Reid, Garry Rumbles, “Ion-pair reorganization regulates reactivity in photoredox catalysts”, Nature Chem. 2022, 14, 746, available online.

Yoonsu Park, Lei Tian, Sangmin Kim, Tyler P. Pabst, Junho Kim, Gregory D. Scholes, Paul J. Chirik, “Visible-Light-Driven, Iridium-Catalyzed Hydrogen Atom Transfer: Mechanistic Studies, Identification of Intermediates, and Catalyst Improvements”, JACS Au 2022, 2, 407, available online.

Alexander Reichle, Hannes Sterzel, Peter Kreitmeier, Remi Fayad, Felix N. Castellano, Julia Rehbein, Oliver Reiser, “Copper(ii)-photocatalyzed decarboxylative oxygenation of carboxylic acids”, Chem. Commun. 2022, 58, 4456, available online.

Walter D. Guerra , Hannah J. Sayre , Hunter H. Ripberger , Emmanuel Odella, Gregory D. Scholes , Thomas A. Moore , Robert R. Knowles , Ana L. Moore, “Ir(III)-Naphthoquinone complex as a platform for photocatalytic activity”, J. Photochem. Photobiol. 2022, 9, 100098, available online.

Kuo Zhao, Robert R. Knowles, “Contra-Thermodynamic Positional Isomerization of Olefins”, J. Am. Chem. Soc. 2022, 144, 137, available online.

Paul T. Cesana, Beryl X. Li, Samuel G. Shepard, Stephen I. Ting, Stephanie M. Hart, Courtney M. Olson, Jesus I. Martinez-Alvarado, Minjung Son, Talia J. Steiman, Felix N. Castellano, Abigail G. Doyle, David W. C. MacMillan, Gabriela S. Schlau-Cohen, “A biohybrid strategy for enabling photoredox catalysis with low-energy light”, Chem 2022, 8, 174, available online.

Bryce Nicholls, Daniel Oblinsky, Sarah Kurtoic, Daria Grosheva, Yuxuan Ye, Gregory D. Scholes, Todd Hyster, “Engineering a Non-Natural Enzyme for Improved Photon Efficiency”, Angew. Chem. Int. Ed. 2022, 2, e202113842, available online.

2021

Yoonsu Park, Sangmin Kim, Lei Tian, Hongyu Kim, Gregory D. Scholes, Paul J. Chirik, “Visible light enables catalytic formation of weak chemical bonds with molecular hydrogen”, Nature Chem. 2021, 13, 969, available online.

Alex J. Chinn, Kassandra Sedillo, Abigail G. Doyle, “Phosphine/Photoredox Catalyzed Anti-Markovnikov Hydroamination of Olefins with Primary Sulfonamides via α-Scission from Phosphoranyl Radicals”, J. Am. Chem. Soc. 2021, 143, 18331, available online.

Suong T. Nguyen, Elizabeth A. McLoughlin, James H. Cox, Brett P. Fors, Robert R. Knowles, “Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage”, J. Am. Chem. Soc. 2021, 143, 12268, available online and explanatory slide.

Hannah Sayre, Hunter H. Ripberger, Emmanuel Odella, Anna Zieleniewska, Daniel A. Heredia, Garry Rumbles, Gregory D. Scholes, Thomas A. Moore, Ana L. Moore, Robert R. Knowles, “PCET-Based Ligand Limits Charge Recombination with an Ir(III) Photoredox Catalyst”, J. Am. Chem. Soc. 2021, 143, 13034, available online and explanatory slide.

Beryl X. Li, Daniel K. Kim, Steven Bloom, Richard Y.-C. Huang, Jennifer X. Qiao, William R. Ewing, Daniel G. Oblinsky, Gregory D. Scholes, David W. C. MacMillan, “Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation”, Nature. Chem. 2021, 13, 902, available online.

Nicholas A. Till, Seokjoon Oh, David W. C. MacMillan, Matthew Bird, “The Application of Pulse Radiolysis to the Study of Ni(I) Intermediates in Ni-Catalyzed Cross-Coupling Reactions”, J. Am. Chem. Soc. 2021, 143, 9332,  available online.

Stavros K. Kariofillis, Abigail G. Doyle, “Synthetic and Mechanistic Implications of Chlorine Photoelimination in Nickel/Photoredox C(sp³)–H Cross-Coupling”, Acc. Chem. Res. 2021, 54, 988, available online.

Hannah Sayre, Lei Tian, Minjung Son, Stephanie M. Hart, Xiao Liu, Daniela Arias-Rotondo, Barry P. Rand, Gabriela Schlau-Cohen, Gregory D. Scholes, “Solar Fuels and Feedstocks: The Quest for Renewable Black Gold”, Energy Environ. Sci. 2021, 14, 1402, available online.

Braddock A. Sandoval, Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, Todd K. Hyster, “Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent ‘Ene’-Reductases”, J. Am. Chem. Soc. 2021, 143, 1735, available online.

2020

Jacob S. DeHovitz, Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamaouchi, David W. C. MacMillan, Todd K. Hyster, “Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones”, Science 2020, 369, 1113, available online.

Remi Fayad, Anh Thy Bui, Samuel G. Shepard, Felix N. Castellano, “Photochemical Upconversion in Water Using Cu(I) MLCT Excited States: Role of Energy Shuttling at the Micellar/Water Interface”, ACS Appl. Energy Mater. 2020, 3, 12557, available online.

Claire G. Page, Simon J. Cooper, Jacob DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Gregory D. Scholes, Todd K. Hyster, “Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins”, J. Am. Chem. Soc. 2021, 143, 97, available online.

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, Gregory D. Scholes, “Active Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes”, J. Phys. Chem. B 2020, 124, 11236, available online.

Nancy Awwad, Anh Thy Bui, Evgeny O. Danilov, Felix N. Castellano, “Visible-Light-Initiated Free-Radical Polymerization by Homomolecular Triplet-Triplet Annihilation”, Chem. 2020, 6, 3071, available online and explanatory slide.

Matthew D. Woodhouse, James K. McCusker, “Mechanistic Origin of Photoredox Catalysis Involving Iron(II) Polypyridyl Chromophores”, J. Am. Chem. Soc. 2020, 142, 16229, available online.

Andrew H. Proppe, Yuguang C. Li, Alán Aspuru-Guzik, Curtis P. Berlinguette, Christopher J. Chang, Richard Cogdell, Abigail G. Doyle, Johannes Flick, Nathaniel M. Gabor, Rienk van Grondelle, Sharon Hammes-Schiffer, Shaffiq A. Jaffer, Shana O. Kelley, Mario Leclerc, Karl Leo, Thomas E. Mallouk, Prineha Narang, Gabriela S. Schlau-Cohen, Gregory D. Scholes, Aleksandra Vojvodic, Vivian Wing-Wah Yam, Jenny Y. Yang, Edward H. Sargent, “Bioinspiration in light harvesting and catalysis” Nature Rev. Mater. 2020, 5, 828, available online.

Hwon Kim, Gregory D. Scholes, “Configuration Mixing Upon Reorganization of Dihedral Angle Induces Rapid Intersystem Crossing in Organic Photocatalyst”, Phys. Chem. Chem. Phys. 2020, 22, 13292, available online.

Elliot J. Taffet, Francesca Fassioli, Zi S.D. Toa, D. Toa, David Beljonne, Gregory D. Scholes, “Uncovering Dark Multichromophoric States in Peridinin-Chlorophyll-Protein”, J. R. Soc. Interface 2020, 17, 20190736, available online.

Nicholas A. Till, Lei Tian, Zhe Dong, Gregory D. Scholes, David W. C. MacMillan, “Mechanistic Analysis of Metallaphotoredox C–N Coupling: Photocatalysis Initiates and Perpetuates Ni(I)/Ni(III) Coupling Activity”, J. Am. Chem. Soc. 2020, 142, 15830, available online.

Lei Tian, Nicholas A. Till, Bryan Kudisch, David W. C. MacMillan, Gregory D. Scholes, “Transient Absorption Spectroscopy Offers Mechanistic Insights for an Iridium/Nickel-Catalyzed C–O Coupling”, J. Am. Chem. Soc. 2020, 142, 4555, available online. 

Hwon Kim, Gregory D. Scholes, “Configuration mixing upon reorganization of dihedral angle induces rapid intersystem crossing in organic photoredox catalyst”, Phys. Chem. Chem. Phys. 2020, 22, 13292, available online.

Remi Fayad, Sebastian Engl, Evgeny O. Danilov, Cory E. Hauke, Oliver Reiser, Felix N. Castellano, “Direct Evidence of Visible Light-Induced Homolysis in Chlorobis(2,9-dimethyl-1,10-phenanthroline)copper(II)”, J. Phys. Chem. Lett. 2020, 11, 5345, available online.

Suong T. Nguyen, Philip R. D. Murray, Robert R. Knowles, “Light-Driven Depolymerization of Native Lignin Enabled by Proton-Coupled Electron Transfer”, ACS Catal. 2020, 10, 800, available online.

Stephen I. Ting, Sofia Garakyaraghi, Chelsea M. Taliaferro, Benjamin J. Shields, Gregory D. Scholes, Felix N. Castellano, Abigail G. Doyle, “³d-d Excited States of Ni(II) Complexes Relevant to Photoredox Catalysis: Spectroscopic Identification and Mechanistic Implications”, J. Am. Chem. Soc. 2020, 142, 5800, available online. 

 

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory D. Scholes, Todd K. Hyster, “Asymmetric Redox-Neutral Radical Cyclization Catalyzed by Flavin-Dependent ‘Ene’-Reductases”, Nature Chem. 2020, 12, 71, available online.

2019

Elliot Taffet, Benjamin G. Lee, Zi Siang Desmond Toa, Natalie Pace, Garry Rumbles, June Southall, Richard Cogdell, Gregory Scholes, “Carotenoid Nuclear Motion Induces the Realization of a Dark First Excited State”, J. Phys. Chem. B 2019, 123, 8628, available online.

Jonathan Huff, Paul Davis, Allison Christy, Donald Kellis, Nirmala Kandadai, Desmond Zi Siang Toa, Gregory D. Scholes, Bernard Yurke, William Knowlton, Ryan Pensack, “DNA-Templated Aggregates of Strongly-Coupled Cyanine Dyes: Nonradiative Decay Governs Exciton Lifetime”, J. Phys. Chem. Lett. 2019, 10, 2386, available online.

Zi S. D. Toa, Mary Helen deGolian, Chanelle C. Jumper, Roger G. Hiller, Gregory D. Scholes, “A Consistent Model of Ultrafast Energy Transfer in Peridinin Chlorophyll-a Protein Using Two-Dimensional Electronic Spectroscopy and Forster Theory”, J. Phys. Chem. B 2019, 123, 6410, available online.

Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, Todd K. Hyster, “Photoexcitation of flavoenzymes enables a stereoselective radical cyclization”, Science, 2019, 364, 1166, available online.

Zi S. D. Toa, Jacob C. Dean, Gregory D. Scholes, “Revealing Structural Involvement of Chromophores in Algal Light Harvesting Complexes using Symmetry-Adapted Perturbation Theory”, J. Photochem. Photobiol. B. 2019, 190, 110, available online.

Hsin-Ya Kuo, Tia Lee, An Chu, Steven Tignor, Gregory D. Scholes, Andrew Bocarsly, “A cyanide-bridged di-manganese carbonyl complex that photochemically reduces CO₂ to CO”, Dalton Trans. 2019, 48, 1226, available online.